Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties
Zhangcheng Chen, Luyu Fan, Huan Wang, Jing Yu, Dengyu Lu, Jianzhong Qi, Fen Nie, Zhipu Luo, Zhen Liu, Jianjun Cheng, Sheng Wang
Topics & Concepts
Partial agonistAgonistPharmacophoreDopamine receptor D2AripiprazolePharmacologyChemistry5-HT receptorAntidepressantAntipsychoticNeuroscienceSchizophrenia (object-oriented programming)DopamineReceptorSerotoninPsychologyMedicineHippocampusPsychiatryStereochemistryBiochemistryReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research