Organoids as a tool in drug discovery and patient-specific therapy for head and neck cancer
Aaron J. Done, Andrew C. Birkeland
Abstract
Organoids more accurately reflect tumor microenvironment than traditional models. Millen et al. demonstrated organoids replicated from patient tissues may predict patient-specific response to radiation therapy and have potential to be utilized for validation of biomarkers in drug discovery and treatment planning.
Topics & Concepts
OrganoidDrug discoveryRadiation therapyHead and neck cancerMedicineTumor microenvironmentHead and neckDrugCancerCancer therapyOncologyComputational biologyBioinformaticsMedical physicsInternal medicineBiologyPharmacologyNeuroscienceSurgeryLung Cancer Treatments and MutationsCancer Cells and MetastasisRNA modifications and cancer