Adjudin-loaded redox-sensitive paclitaxel-prodrug micelles for overcoming multidrug resistance with efficient targeted Colon cancer therapy
Deli Chen, Sitang Ge, Lugen Zuo, Shuanhu Wang, Mulin Liu, Shiqing Li
Abstract
-P/A can effectively reverse MDR by increasing cell uptake, inhibiting PTX efflux, and improving drug release.
Topics & Concepts
ProdrugPaclitaxelPharmacologyMultiple drug resistanceIn vivoMicelleChemotherapyCancer cellDrug deliveryCancer researchDrug resistanceCancerMedicineChemistryBiologyInternal medicinePhysical chemistryAqueous solutionBiotechnologyOrganic chemistryMicrobiologyDrug Transport and Resistance MechanismsNanoparticle-Based Drug DeliveryMetal complexes synthesis and properties