Litcius/Paper detail

Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia

Yanxin Li, Jianwei Jiao

2020Science Advances289 citationsDOIOpen Access PDF

Abstract

In short, this study reveals the complicated interplay between TRPM2 and β-Cat/SP5 signaling during heat stress.

Topics & Concepts

NeurogenesisTRPM2Embryonic stem cellHeat stressHyperthermiaCell biologyBiologyMalignant hyperthermiaNeuroscienceTransgeneMedicineGeneticsPathologyGeneReceptorAnimal scienceTransient receptor potential channelPaleontologyIon Channels and ReceptorsNeurobiology and Insect Physiology ResearchIon channel regulation and function