An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design
Hanlu Gao, Wei Wang, Jie Dong, Zhuyifan Ye, Defang Ouyang
Topics & Concepts
Physiologically based pharmacokinetic modellingDissolutionSupersaturationDispersion (optics)Dissolution testingBiological systemBioavailabilityComputer scienceChemistryPharmacokineticsBiochemical engineeringPharmacologyEngineeringPhysicsBiopharmaceutics Classification SystemBiologyMedicineOrganic chemistryOpticsPhysical chemistryDrug Solubulity and Delivery SystemsProtein purification and stabilityAnalytical Chemistry and Chromatography