Antimalarial Activity of Highly Coordinative Fused Heterocycles Targeting β<i>-</i>Hematin Crystallization

Abstract

model. The complexation ability of the ligands with iron(III) was experimentally and theoretically determined, finding, in general, a good correlation between the complexation ability of the ligand and the inhibitory activity toward β-hematin crystallization. These findings open new perspectives toward the rational design of antimalarial β-hematin inhibitors based on the coordinative character as an alternative to the conventional β-hematin inhibitors.

Topics & Concepts