BMP8 and activated brown adipose tissue in human newborns
Adela Urisarri, Ismael González‐García, Ánxela Estévez‐Salguero, María P. Pata, Edward Milbank, Noemí López, Natalia Mandiá, Carmen Grijota-Martínez, Carlos A. Salgado, Rubén Nogueiras, Carlos Diéguez, Francesc Villarroya, José Manuel Fernández‐Real, María L. Couce, Miguel López
Abstract
The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.