Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening
Jian Liu, Jingxian Zhou, Feng-Jun He, Liang Gao, Yuquan Wen, Lina Gao, Ping Wang, Di Kang, Lihong Hu
Topics & Concepts
ChemistryIndazoleHeLaIC50HDAC8Docking (animal)StereochemistryAcetylationCell cycleVirtual screeningCell growthApoptosisBiochemistryCellIn vitroHistone methyltransferasePharmacophoreNursingGeneMedicineHistone Deacetylase Inhibitors ResearchClick Chemistry and ApplicationsProtein Degradation and Inhibitors