Construction of a high fidelity epidermis-on-a-chip for scalable <i>in vitro</i> irritation evaluation
Jing Zhang, Zaozao Chen, Yaoyao Zhang, Xingchi Wang, Jun Ouyang, Jianfeng Zhu, Yu‐Chuan Yan, Xiaowei Sun, Fei Wang, Xiaoran Li, Huan Ye, Shiqi Sun, YU Qing-dong, Jiawei Sun, Jianjun Ge, Qiwei Li, Qianqian Han, Yuepu Pu, Zhongze Gu
Abstract
We constructed an organotypic epidermis-on-a-chip with integrated barrier function that does not use PDMS material and integrates TEER detection. It could be an alternative in irritation testing according to the OECD 439 method.
Topics & Concepts
IrritationSkin irritationChipScalabilityEpidermis (zoology)In vitroFidelityComputer scienceEngineeringChemistryCell biologyBiologyTelecommunicationsDermatologyAnatomyMedicineOperating systemImmunologyBiochemistry3D Printing in Biomedical ResearchNeuroscience and Neural EngineeringAdvancements in Transdermal Drug Delivery