Exploring the Effect of Glycerol and Hydrochloric Acid on Mesoporous Silica Synthesis: Application in Insulin Loading
May Kyaw Oo, Batoul Alallam, Abd Almonem Doolaanea, Alfi Khatib, Farahidah Mohamed, Bappaditya Chatterjee
Abstract
/g. With increasing acid and glycerol concentrations, the particle size of MPS decreased. However, while the glycerol increased the heterogeneity of the synthesized particles, the acid decreased it. The developed MPS was successfully loaded with a biological drug (insulin) with a 21.94% encapsulation efficiency. The MPS prepared in this study exhibits potential applications as a drug delivery carrier for drugs with a large molecular weight.
Topics & Concepts
GlycerolHydrochloric acidMesoporous silicaMesoporous materialInsulinChemistryChemical engineeringOrganic chemistryInternal medicineCatalysisMedicineEngineeringMesoporous Materials and CatalysisAdsorption and biosorption for pollutant removalAerogels and thermal insulation