Bioengineered extracellular vesicle-loaded bioscaffolds for therapeutic applications in regenerative medicine
Sabrina Lazar, Sirjan Mor, Jianing Chen, Dake Hao, Aijun Wan
Abstract
studies, such as in providing enhanced tissue regeneration, EV retention rates, and healing efficacy. Different types of natural biomaterials, synthetic polymers, and ceramics have been developed for EV loading, and these EV functionalized biomaterials have been applied in different areas for disease treatment. The EV functionalized scaffolds can be designed to be biodegradable, off-the-shelf biomaterials as a delivery vehicle for EVs. Overall, the bioengineered EV-loaded bioscaffolds represent a promising approach for cell-free treatment in clinical applications.
Topics & Concepts
Regenerative medicineExtracellular matrixRegeneration (biology)Extracellular vesiclesTissue engineeringVesicleExtracellular vesicleBiomedical engineeringDrug deliveryNanotechnologyMaterials scienceIn vivoChemistryCell biologyCellBiologyMicrovesiclesMedicineBiotechnologyBiochemistryGenemicroRNAMembraneExtracellular vesicles in diseaseTissue Engineering and Regenerative MedicineMicroRNA in disease regulation