Urolithin A protects mice against osteoarthritis by inhibiting chondrocyte ferroptosis through activating AMPK/mTOR/HIF-1α signaling pathway
Xukai Wang, Q. Alan Xu, Jinzheng Huang, Yating Gao, Fangliang Zheng, Guangyao Liu
Topics & Concepts
ChemistryChondrocyteMMP3AMPKDownregulation and upregulationPharmacologyPI3K/AKT/mTOR pathwayViability assaySignal transductionCurcuminMAPK/ERK pathwayNitric oxideGlutathioneProtein kinase ABiochemistryProtein kinase BAndrographolideInflammationMTT assayCell biologyKinaseOsteoarthritisAntioxidantWestern blotCartilageMatrix metalloproteinaseOxidative stressCarnosic acidNF-κBMMP9Nitric oxide synthaseCancer researchPomegranate: compositions and health benefitsPhytase and its ApplicationsConnective Tissue Growth Factor Research