Pseudouridine and <i>N</i>1-methylpseudouridine as potent nucleotide analogues for RNA therapy and vaccine development
Lyana L. Y. Ho, Gabriel H. A. Schiess, Pâmella Miranda, Gerald Weber, Kira Astakhova
Abstract
1-methylpseudouridine in mRNA drug candidates. We also highlight remaining challenges that need to be solved to develop new mRNA vaccines and therapies.
Topics & Concepts
PseudouridineRNANucleotideVirologyComputational biologyBiologyMedicineGeneticsTransfer RNAGeneRNA Interference and Gene DeliveryRNA modifications and cancerVirus-based gene therapy research