Sex Differences in Clinical Outcomes After Percutaneous Coronary Intervention
Yasuaki Takeji, Takeshi Morimoto, Hiroki Shiomi, Eri Kato, Kazuaki Imada, Yusuke Yoshikawa, Yukiko Matsumura‐Nakano, Ko Yamamoto, Kyohei Yamaji, Toshiaki Toyota, Tomohisa Tada, Junichi Tazaki, Erika Yamamoto, Kenji Nakatsuma, Satoru Suwa, Natsuhiko Ehara, Ryoji Taniguchi, Toshihiro Tamura, Hiroki Watanabe, Mamoru Toyofuku, Takashi Yamamoto, Eiji Shinoda, Hiroshi Mabuchi, Moriaki Inoko, Tomoya Onodera, Hiroki Sakamoto, Tsukasa Inada, Kenji Andò, Yutaka Furukawa, Yukihito Sato, Kazushige Kadota, Yoshihisa Nakagawa, Takeshi Kimura
Abstract
BACKGROUND: There is a scarcity of studies comparing the clinical outcomes after percutaneous coronary intervention (PCI) for women and men stratified by the presentation of acute coronary syndromes (ACS) or stable coronary artery disease (CAD). METHODS AND RESULTS: The study population included 26,316 patients who underwent PCI (ACS: n=11,119, stable CAD: n=15,197) from the CREDO-Kyoto PCI/CABG registry Cohort-2 and Cohort-3. The primary outcome was all-cause death. Among patients with ACS, women as compared with men were much older. Among patients with stable CAD, women were also older than men, but with smaller difference. The cumulative 5-year incidence of all-cause death was significantly higher in women than in men in the ACS group (26.2% and 17.9%, log rank P<0.001). In contrast, it was significantly lower in women than in men in the stable CAD group (14.2% and 15.8%, log rank P=0.005). After adjusting confounders, women as compared with men were associated with significantly lower long-term mortality risk with stable CAD but not with ACS (hazard ratio [HR]: 0.75, 95% confidence interval [CI]: 0.69-0.82, P<0.001, and HR: 0.92, 95% CI: 0.84-1.01, P=0.07, respectively). There was a significant interaction between the clinical presentation and the mortality risk of women relative to men (interaction P=0.002). CONCLUSIONS: Compared with men, women had significantly lower adjusted mortality risk after PCI among patients with stable CAD, but not among those with ACS.