Discovery of the cereblon-recruiting tubulin PROTACs effective in overcoming Taxol resistance in vitro and in vivo
Hua Yang, Jinling Qin, Yuanyuan Pei, Sumeng Guan, Mei Zhao, Yingge Wang, Yongfang Yao, Yongtao Duan, Moran Sun
Topics & Concepts
TubulinIn vivoMicrotubuleChemistryProteasomeCereblonIn vitroCell cultureA549 cellDrug discoveryCancer researchCell biologyUbiquitinBiochemistryBiologyUbiquitin ligaseGeneticsGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways