N-Linked Glycans Shape Skin Immune Responses during Arthritis and Myositis after Intradermal Infection with Ross River Virus
Kothila Tharmarajah, Arun Everest‐Dass, Jelena Vider, Xiang Liu, Joseph R. Freitas, Helen Mostafavi, Jayaram Bettadapura, Mark von Itzstein, Nicholas P. West, Adam Taylor, Suresh Mahalingam, Ali Zaid
Abstract
Arthritogenic alphaviruses are transmitted via mosquito bites through the skin, potentially causing debilitating diseases. Our understanding of how viral infection starts in the skin and how virus systemically disseminates to cause disease remains limited. Intradermal arbovirus infection described herein results in musculoskeletal pathology, which is dependent on viral envelope N-linked glycosylation. As such, intradermal infection route provides new insights into how arboviruses cause disease and could be extended to future investigations of skin immune responses following infection with other re-emerging arboviruses.