A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma
Ping Tan, Weihua Zhuang, Shufen Li, Jiapeng Zhang, Hang Xu, Lu Yang, Yanbiao Liao, Mao Chen, Qiang Wei
Abstract
A one-step synthesized LD specific fluorescent probe TTIE with high specificity, good photostability and great capacity in generating cytotoxic reactive oxygen species (ROS) under low powered white light irradiation is designed and synthesized for LD specific image-guided photodynamic therapy (PDT) in human clear cell renal cell carcinoma (ccRCC) primary cells and tissues.
Topics & Concepts
Photodynamic therapyFluorescenceRenal cell carcinomaCancer researchCarcinomaCellChemistryPathologyBiophysicsMaterials scienceMedicineOpticsBiologyBiochemistryPhysicsOrganic chemistrySpectroscopy Techniques in Biomedical and Chemical ResearchNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials