Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy
Chonglu Li, Le Tu, Jingfang Yang, Chang Liu, Yuling Xu, Junrong Li, Wei Tuo, Bogdan Olenyuk, Yan Sun, Peter J. Stang, Yao Sun
Abstract
studies confirm that Ru4 allows for effective and safe phototherapy against A549 tumors. This work thus is expected to open a new avenue for the design of high-performance metal-based photosensitizers for potential clinical applications.
Topics & Concepts
PhototoxicityPhotodynamic therapySinglet oxygenPhotochemistryReactive oxygen speciesChemistryRutheniumAcceptorCombinatorial chemistryNanotechnologyMaterials scienceOxygenIn vitroBiochemistryOrganic chemistryCatalysisPhysicsCondensed matter physicsNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesLuminescence and Fluorescent Materials