A VersaTile-driven platform for rapid hit-to-lead development of engineered lysins
Hans Gerstmans, Dennis Grimon, Dolores Gutiérrez, Cédric Lood, Ana Rodrı́guez, Vera van Noort, Jeroen Lammertyn, Rob Lavigne, Yves Briers
Abstract
in human serum and an ex vivo pig burn wound model. This generic platform could offer new opportunities to populate the preclinical pipeline with engineered lysins for diverse (therapeutic) applications.
Topics & Concepts
LysinPipeline (software)Lead (geology)Computer scienceNanotechnologyBiologyMaterials scienceGeneticsGeneProgramming languagePaleontologyBacteriophageEscherichia coliBacteriophages and microbial interactionsClick Chemistry and ApplicationsChemical Synthesis and Analysis