Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19
Igor Longobardi, Danilo Marcelo Leite do Prado, Karla Fabiana Goessler, Matheus Molina Meletti, Gersiel Nascimento de Oliveira Júnior, Danieli Andrade, Bruno Gualano, Hamilton Roschel
Abstract
Our findings provide novel data regarding the impact of COVID-19 on submaximal and maximal cardiopulmonary responses to exercise. We showed that V̇o 2 kinetics is significantly impaired at both the onset (on-transient) and the recovery phase (off-transient) of exercise in these patients. Furthermore, our results suggest that survivors of severe COVID-19 may have a higher metabolic demand at a walking pace. These findings may partly explain the exertional intolerance frequently observed following COVID-19.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)ChronotropicMedicineCardiology2019-20 coronavirus outbreakOxygenInternal medicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Intensive care medicineHeart rateChemistryVirologyDiseaseBlood pressureInfectious disease (medical specialty)Organic chemistryOutbreakCardiovascular and exercise physiologyHeart Rate Variability and Autonomic ControlLong-Term Effects of COVID-19