Cell-Intrinsic CD38 Expression Sustains Exhausted CD8 <sup>+</sup> T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection
Julia M. DeRogatis, Emily N. Neubert, Karla M. Viramontes, Monique L. Henriquez, Dequina Nicholas, Roberto Tinoco
Abstract
Our study shows how CD38 expression is regulated on CD8 + T cells responding during acute and chronic viral infection. We observed higher CD38 levels on CD8 + T cells during chronic viral infection compared to levels during acute viral infection.
Topics & Concepts
CD38BiologyCD8Viral infectionChronic infectionVirologyViral loadCytotoxic T cellVirusViral replicationImmune systemImmunologyCell biologyIn vitroStem cellGeneticsCD34Calcium signaling and nucleotide metabolismImmune Cell Function and InteractionAdenosine and Purinergic Signaling