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ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma

Min Wang, Guang Zeng, Bingrui Xiong, Xiaobin Zhu, Jia Guo, Danyang Chen, Shanshan Zhang, Min Luo, Liang Guo, Lin Cai, Lin Cai

2023Biochemical Pharmacology78 citationsDOI

Topics & Concepts

AutophagyAMPKPI3K/AKT/mTOR pathwayCell biologyChemistryULK1Cancer researchMelanomaBiologySignal transductionKinaseProtein kinase AApoptosisBiochemistryFerroptosis and cancer prognosisCancer-related molecular mechanisms researchAutophagy in Disease and Therapy
ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma | Litcius