Litcius/Paper detail

Biomineralized nanoparticles enable an enzyme-assisted DNA signal amplification in living cells

Mengyi Xiong, Meng Zhang, Qin Liu, Chan Yang, Qingji Xie, Guoliang Ke, Hong‐Min Meng, Xiaobing Zhang, Weihong Tan

2020Chemical Communications22 citationsDOI

Abstract

The enzymatic-assisted signal amplification of DNA sensors is rarely applied in living cells due to the difficulties in protein delivery. In this study, we have proposed a biomineralization-based DNA nanoprobe to transport nucleases and DNA sensors for enzyme-assisted imaging of microRNA in living cells.

Topics & Concepts

DNANanoparticleNanotechnologyEnzymeBiophysicsSIGNAL (programming language)ChemistryMaterials scienceBiochemistryBiologyComputer scienceProgramming languageAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in MaterialsDNA and Nucleic Acid Chemistry