Immunothrombosis and thromboinflammation in host defense and disease
Kimberly Martinod, Carsten Deppermann
Abstract
Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.
Topics & Concepts
Neutrophil extracellular trapsPlateletHemostasisInnate immune systemImmunologySepsisGPVIThrombosisInflammationChemokineMedicineReceptorImmune systemPlatelet activationSecretionInternal medicineNeutrophil, Myeloperoxidase and Oxidative MechanismsVenous Thromboembolism Diagnosis and ManagementInflammasome and immune disorders