Morphine mediated neutrophil infiltration in intestinal tissue play essential role in histological damage and microbial dysbiosis
Richa Jalodia, Udhghatri Kolli, Regina Gonzalez Braniff, Junyi Tao, Yaa Abu, Irina Chupikova, Shamsudheen Moidunny, Sundaram Ramakrishnan, Sabita Roy
Abstract
. Taken together, we provide the first direct evidence that neutrophil infiltration contributes to morphine-induced intestinal tissue damage and gut microbial dysbiosis. Our findings implicate that inhibition of neutrophil infiltration may provide therapeutic benefits against gastrointestinal dysfunctions associated with opioid use.
Topics & Concepts
DysbiosisBiologyInfiltration (HVAC)Immune systemInflammationMicrobiomeImmunologyMicrobiologyChemokineIntestinal mucosaAntibioticsGut floraMedicineInternal medicineBioinformaticsPhysicsThermodynamicsGut microbiota and healthClostridium difficile and Clostridium perfringens researchTryptophan and brain disorders