Rh(III)‐Catalyzed C−H Activation/Annulation of Aryl Hydroxamates with CF<sub>3</sub>‐Containing <i>α</i>‐Propargyl <i>α</i>‐Amino Acid Derivatives
Daria V. Vorobyeva, Dmitry A. Petropavlovskikh, Ivan A. Godovikov, С.Е. Нефедов, Sergey N. Osipov
Abstract
Abstract A series of new orthogonally protected α ‐CF 3 ‐substituted α ‐amino carboxylates, and α‐amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)‐catalyzed C−H activation/annulation of aryl hydroxamates with propargyl‐containing α ‐amino acid derivatives and their phosphorus analogues.
Topics & Concepts
ChemistryAnnulationPropargylPharmacophoreArylCatalysisAmino acidStereochemistryMedicinal chemistryOrganic chemistryAlkylBiochemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsFluorine in Organic Chemistry