Onion (<i>Allium cepa</i>) and its Main Constituents as Antidotes or Protective Agents against Natural or Chemical Toxicities: A Comprehensive Review.
Mahyar Dorrigiv, Armin Zareiyan, Hossein Hosseinzadeh
Abstract
and animal studies on the protective effects of onion against natural and chemical toxicities. Onion and its main components can ameliorate the toxicity of chemical agents in kidney, liver, brain, blood, heart, reproductive system, embryo, pancreas through reducing lipid peroxidation, antioxidant effect, radical-scavenging, anti-inflammatory, chelating agent, cytoprotective activities, increasing protein synthesis in damaged tissues, suppressing apoptosis, as well as modulation of PKC-𝜀/p38MAPK, Wnt/beta-Catenin, ERK, JNK, p38 MAPK, Bcl-2, Bax, and NF-κB signaling pathways.
Topics & Concepts
AlliumTraditional medicineChemical constituentsNatural (archaeology)ToxicologyChemistryPharmacologyMedicineBiologyBotanyChromatographyPaleontologyGarlic and Onion StudiesNigella sativa pharmacological applicationsPineapple and bromelain studies