Silver-catalyzed P-centered anion nucleophilic addition to isocyanide: access to 2-phosphinoyl indoles/indol-3-ols
Yong Liu, Mengying Jia, Guodong Wang, Wenhui Yang, Xianxiu Xu
Abstract
A silver-catalyzed P-centered anion-initiated cascade reaction of functionalized arylisocyanides with H-phosphorus oxides was established for the expeditious synthesis of various 2-phosphinoyl-indole/-indol-3-ol derivatives.
Topics & Concepts
Indole testIsocyanideNucleophileCatalysisChemistryNucleophilic additionIonMedicinal chemistryCombinatorial chemistryCascadeStereochemistryOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis of Indole Derivatives