Intersection of H2S and Nrf2 signaling: Therapeutic opportunities for neurodegenerative diseases
Priyanka Soni, Shravan Paswan, Bindu D. Paul, Bobby Thomas
Abstract
S and Nrf2 signaling underscores their potential as endogenous regulators of cellular resilience against neurodegeneration. Understanding how gasotransmitters fine-tune the Nrf2-Keap1 pathway opens up new avenues for therapeutic interventions in these neurodegenerative disorders. By elucidating how gasotransmitters influence Nrf2-mediated responses, we aim to underscore promising therapeutic strategies that target oxidative damage, modulate neuroinflammation, and enhance neuronal survival pathways in neurodegenerative diseases.
Topics & Concepts
KEAP1NeurodegenerationNeuroinflammationOxidative stressNeuroscienceNeuroprotectionProteostasisSignal transductionBiologyCell signalingCell biologyDiseaseTranscription factorInflammationMedicineImmunologyBiochemistryPathologyGeneGenomics, phytochemicals, and oxidative stressSulfur Compounds in BiologyCircadian rhythm and melatonin