CoH-catalyzed asymmetric remote hydroalkylation of heterocyclic alkenes: a rapid approach to chiral five-membered S- and O-heterocycles
Lingzi Zhao, Feipeng Liu, Yan Zhuang, Mengyang Shen, Jing Xue, Xuchao Wang, Yuting Zhang, Zi‐Qiang Rong
Abstract
A highly efficient method achieves precise construction of alkyl chiral centers at remote C3-positions in five-membered S/O-heterocycles via cobalt-catalyzed asymmetric remote hydroalkylation of heterocyclic alkenes.
Topics & Concepts
CatalysisAlkylCombinatorial chemistryChemistryCobaltStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis