CD4 <sup>+</sup> T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis
Qing Zhao, Lennard W. Duck, Fengyuan Huang, Katie L. Alexander, Craig L. Maynard, Peter Mannon, Charles O. Elson
Abstract
) cells that provide antigen-specific and bystander suppression, supporting a potential immunotherapy to prevent or ameliorate IBD.
Topics & Concepts
PI3K/AKT/mTOR pathwayColitisInflammationFlagellinChemistryEpitopeCancer researchBiologyCell biologyImmunologyBiochemistrySignal transductionAntigenReceptorImmune Cell Function and InteractionImmunotherapy and Immune ResponsesT-cell and B-cell Immunology