Novel asymmetric biscarbothioamides as Alzheimer's disease associated cholinesterase inhibitors: synthesis, biological activity, and molecular docking studies
Halit Muğlu, Hasan Yakan, Musa Erdoğan, Fevzi Topal, Meryem Topal, Cüneyt Türkeş, Şükrü Beydemir
Abstract
Investigating innovative frameworks for addressing Alzheimer's disease is a challenging goal. In this specific scenario, a selection of asymmetric biscarbothioamide derivatives (3a–l) with different substitutions has been carefully formulated and successfully synthesized.
Topics & Concepts
ChemistryCholinesteraseDocking (animal)ButyrylcholinesterasePharmacologyAcetylcholinesteraseBiochemistryComputational biologyEnzymeAchéMedicineBiologyNursingComputational Drug Discovery MethodsCholinesterase and Neurodegenerative DiseasesSynthesis and biological activity