Glycosaminoglycans: What Remains To Be Deciphered?
Serge Pérez, Olga Makshakova, Jesús Angulo, Emiliano Bedini, Antonella Bisio, José L. de Paz, Elisa Fadda, Marco Guerrini, Michal Hricovíni, Miloš Hricovı́ni, Frédérique Lisacek, Pedro M. Nieto, Kevin Pagel, Giulia Paiardi, Ralf P. Richter, Sergey A. Samsonov, Romain R. Vivès, Dragana Nikitovic, Sylvie Ricard‐Blum
Abstract
, ion mobility-mass spectrometry), gas-phase infrared spectroscopy, recognition tunnelling nanopores, and molecular modeling to identify bioactive GAG sequences, biophysical methods to investigate binding interfaces, and to expand our knowledge and understanding of glycocodes governing GAG molecular recognition, and (iii) artificial intelligence for in-depth investigation of GAGomic data sets and their integration with proteomics.
Topics & Concepts
Context (archaeology)Computational biologyChemistryGlycosaminoglycanProteomicsMass spectrometryProteoglycanExtracellular matrixBiochemistryBiologyGeneChromatographyPaleontologyProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis