Rapid hemostasis and high bioactivity cerium‐containing mesoporous bioglass for hemostatic materials

Jiaxi Liu, Xiang Zhou, Yin Zhang, Anping Wang, Wei Zhu, Meijia Xu, Shuxian Zhuang

2021Journal of Biomedical Materials Research Part B Applied Biomaterials20 citationsDOI

Abstract

A two-step-acid-catalyzed-self-assembly method was used to prepare cerium-containing mesoporous bioactive glass with P123 as a template. The results showed that MBG without cerium and MBG with cerium slightly affected its surface area, and its water absorption rate was significantly higher. In vitro coagulation experiments showed that Ce-MBG significantly reduces prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating that MBG containing Ce could promote coagulation and platelet adhesion compared with MBG. These suggested that Ce-MBG may be a good dressing with hemostatic properties, which could shorten the bleeding time of the wound and control the bleeding.

Topics & Concepts

CeriumPartial thromboplastin timeHemostasisMesoporous materialProthrombin timeCoagulationChemistryMaterials scienceBioactive glassNuclear chemistryCatalysisInorganic chemistrySurgeryMedicineOrganic chemistryComposite materialInternal medicineHemostasis and retained surgical itemsPeriodontal Regeneration and TreatmentsSurgical Sutures and Adhesives