In situ T-cell transfection by anti-CD3-conjugated lipid nanoparticles leads to T-cell activation, migration, and phenotypic shift
Azadeh Kheirolomoom, Aris J. Kare, Elizabeth S. Ingham, Ramasamy Paulmurugan, Elise Robinson, Mo Baikoghli, Mohammed Inayathullah, Jai Woong Seo, James Wang, Brett Z. Fite, Bo Wu, Spencer K. Tumbale, Marina N. Raie, R. Holland Cheng, Lisa Nichols, Alexander D. Borowsky, Katherine W. Ferrara
Topics & Concepts
T cellJurkat cellsIL-2 receptorTransfectionCell biologyAntigen-presenting cellMolecular biologyBiologyImmunologyCell cultureImmune systemGeneticsCAR-T cell therapy researchRNA Interference and Gene DeliveryImmunotherapy and Immune Responses