Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability
Shujing Xu, Lin Sun, Alexej Dick, Waleed A. Zalloum, Tianguang Huang, Megan E. Meuser, Xujie Zhang, Yucen Tao, Srinivasulu Cherukupalli, Dang Ding, Xiao Ding, Shenghua Gao, Xiangyi Jiang, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Xinyong Liu, Peng Zhan
Topics & Concepts
ChemistryMoietyBenzothiazoleMetabolic stabilityCapsidHuman immunodeficiency virus (HIV)Lead compoundViral replicationIn silicoStereochemistryPharmacologyBiochemistryVirusIn vitroVirologyBiologyGeneHIV Research and TreatmentHIV/AIDS drug development and treatmentHepatitis C virus research