Short term, low dose alpha-ketoglutarate based polymeric nanoparticles with methotrexate reverse rheumatoid arthritis symptoms in mice and modulate T helper cell responses
Joslyn L. Mangal, Sahil Inamdar, Abhirami P. Suresh, Madhan Mohan Chandra Sekhar Jaggarapu, Arezoo Esrafili, Nathan D. Ng, Abhinav P. Acharya
Abstract
) responses when CIA treated splenic cells were isolated and re-exposed to the CIA self-antigen. Overall, this study supports the concurrent and short term, low dose of paKG NPs and methotrexate for the reversal of RA symptoms.
Topics & Concepts
Rheumatoid arthritisMethotrexateChemistryAlpha (finance)ImmunologyCancer researchMedicineSurgeryPatient satisfactionConstruct validityRheumatoid Arthritis Research and TherapiesCytokine Signaling Pathways and InteractionsHER2/EGFR in Cancer Research