Autocatalytic DNAzyme assembly for amplified intracellular imaging
Keke Gong, Qiong Wu, Hong Wang, Shizhen He, Jinhua Shang, Fuan Wang
Abstract
The autocatalytic HCR-DNAzyme platform was constructed as a versatile amplification platform for intracellular microRNA imaging by integrating hybridization chain reaction (HCR) circuit with DNAzyme biocatalysis. The HCR-assembled multifunctional DNAzyme nanowires produce new HCR triggers and numerous transducer DNAzyme amplifier, and thus shows great promise in earlier cancer diagnosis.
Topics & Concepts
DeoxyribozymeIntracellularAutocatalysisChemistryNanotechnologyBiophysicsCell biologyCatalysisBiochemistryDNABiologyMaterials scienceAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry