Albumin-conjugation enables improved tumor targeting of aptamers via SPECT imaging
Shaowen Yang, Chengwen Zheng, Sixuan Cheng, Wen Li, Pinghui Li, Jianbo Li, Xiaoli Lan, Dawei Jiang
Abstract
. The pharmacokinetic analysis and tumor SPECT imaging studies revealed that HSA-AS1411 had over 14 times longer circulation half-life and superior tumor uptake than those of AS1411. The immunofluorescence staining of tumor tissues further indicated the improved tumor retention of AS1411 as a result of prolonged blood circulation. Therefore, the HSA-conjugated strategy has a promising prospect in improving aptamers' tumor targeting for clinical applications.
Topics & Concepts
AptamerSpect imagingAlbuminBiomedical engineeringCancer researchComputational biologyChemistryMedicineNuclear medicineMolecular biologyBiologyInternal medicineAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryBiosensors and Analytical Detection