Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products
Gao Bo, Bo Yang, Xudong Feng, Chun Li
Abstract
, pyrrole, piperidine, diketopiperazine, and isoquinoline), the engineering of tailoring enzymes, and enzyme cascades constructed to synthesize NHNPs are discussed. In the microbial cell factory part, with tropane alkaloids (TAs) and tetrahydroisoquinoline (THIQ) alkaloids as the representative compounds, the strategies of unraveling unknown natural biosynthesis pathways of NHNPs in plants are summarized, and various metabolic engineering strategies to enhance their production in microbes are introduced. Ultimately, future perspectives for accelerating the biosynthesis of NHNPs are discussed.
Topics & Concepts
NitrogenBiosynthesisChemistryOrganic chemistryCombinatorial chemistryEnzymeMicrobial Natural Products and BiosynthesisChemical synthesis and alkaloidsTraditional and Medicinal Uses of Annonaceae