Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and T <sub>H</sub> 17 responses
Youhui Si, Qiaomu Tian, Fan Zhao, Sean H. Kelly, Lucas Shores, Daniel F. Camacho, Anne I. Sperling, Michael S. Andrade, Joel H. Collier, Anita S. Chong
Abstract
17 cells occurring independently in both LN and lung. Thus, self-assembling peptide nanofiber vaccines may represent a novel, needle- and adjuvant-free means of eliciting protective immunity against fungal and bacterial infections at skin and mucosal barrier surfaces.
Topics & Concepts
AdjuvantDendritic cellPriming (agriculture)Nasal administrationT cellLungImmunologyAntigen presentationAntigen-presenting cellNanofiberAntigenVaccinationMedicineImmune systemBiologyMaterials scienceNanotechnologyInternal medicineBotanyGerminationImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryInhalation and Respiratory Drug Delivery