Pseudomonas aeruginosa Alters Peptidoglycan Composition under Nutrient Conditions Resembling Cystic Fibrosis Lung Infections
Erin M. Anderson, Neethu Shaji Saji, Alexander C. Anderson, Dyanne Brewer, Anthony J. Clarke, Cezar M. Khursigara
Abstract
Using peptidoglycomics to examine the global composition of the peptidoglycan (PG) allows insights into the enzymatic activity that functions on this important biopolymer. Changes within the PG structure have implications for numerous physiological processes, including virulence and antimicrobial resistance. The identification of highly unique PG modifications illustrates the complexity of this biopolymer in Pseudomonas aeruginosa. Analyzing the PG composition of clinical P. aeruginosa epidemic strains provides insights into the increased virulence and antimicrobial resistance of these difficult-to-eradicate infections.
Topics & Concepts
Cystic fibrosisPseudomonas aeruginosaPeptidoglycanMicrobiologyLungBiologyComposition (language)Lung infectionBacteriaMedicineInternal medicineGeneticsLinguisticsPhilosophyProbiotics and Fermented FoodsCystic Fibrosis Research AdvancesBacterial Genetics and Biotechnology