Homogeneous oxidation of C–H bonds with <i>m</i>-CPBA catalysed by a Co/Fe system: mechanistic insights from the point of view of the oxidant
Oksana V. Nesterova, Maxim L. Kuznetsov, Armando J. L. Pombeiro, Georgiy B. Shul’pin⊗, Dmytro S. Nesterov
Abstract
A Co/Fe system efficiently catalyses the oxidation of C–H bonds with m -CPBA. The nitric acid promoter hampers the m -CPBA homolysis, suppressing the free radical activity. Experimental and computational data evidence a concerted oxidation mechanism.
Topics & Concepts
HomolysisCatalysisHomogeneousNitric acidChemistryMechanism (biology)StereochemistryComputational chemistryCombinatorial chemistryPhotochemistryRadicalOrganic chemistryPhilosophyThermodynamicsPhysicsEpistemologyMetal-Catalyzed Oxygenation MechanismsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods