Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke
Min‐Ho Nam, Jongwook Cho, Dae‐Hyuk Kwon, Jiyoung Park, Junsung Woo, Jung Moo Lee, Sangwon Lee, Hae Young Ko, Woojin Won, Ra Gyung Kim, Hanlim Song, Soo‐Jin Oh, Ji Won Choi, Ki Duk Park, Eunkyung Park, Haejin Jung, Hyung-Seok Kim, Min Cheol Lee, Mijin Yun, C. Justin Lee, Hyoung-Ihl Kim
Abstract
(Cell Reports 32, 107861-1–14.e1–e7; July 7, 2020) In the originally published version of this article, the author name Jung Moo Lee was spelled incorrectly. This has now been corrected online. The authors regret this error. Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical StrokeNam et al.Cell ReportsJuly 07, 2020In BriefNam et al. demonstrate that excessive GABA from reactive astrocytes accounts for cortical glucose hypometabolism followed by subcortical stroke and impedes rehabilitation-aided motor functional recovery by aberrantly suppressing motor cortical neuronal activity. Thus, MAO-B, the astrocytic GABA-synthesizing enzyme, can be a therapeutic target for functional recovery after subcortical stroke. Full-Text PDF Open Access