Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration
Hiroshi Kumagai, Su‐Jeong Kim, Brendan Miller, Toshiharu Natsume, Junxiang Wan, Michi Emma Kumagai, Ricardo Ramírez, Shin Hyung Lee, Ayaka Sato, Hemal H. Mehta, Kelvin Yen, Pinchas Cohen
Abstract
MOTS-c, a mitochondrial microprotein, attenuates immobilization-induced skeletal muscle atrophy. MOTS-c treatment improves systemic inflammation and skeletal muscle AKT/FOXOs signaling pathways. Furthermore, unbiased RNA sequencing and subsequent assays revealed that MOTS-c prevents lipid infiltration in skeletal muscle. Since lipid accumulation is one of the common pathologies among other skeletal muscle atrophies induced by aging, obesity, cancer cachexia, and denervation, MOTS-c treatment could be effective in other muscle atrophy models as well.
Topics & Concepts
Skeletal muscleEndocrinologyInternal medicinePeroxisome proliferator-activated receptorMuscle atrophyReceptorAtrophyChemistryBiologyMolecular biologyMedicineGDF15 and Related BiomarkersNutrition and Health in AgingMuscle Physiology and Disorders