Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors
Fatma Babikr, Jiangbo Wan, Aizhang Xu, Zhaojia Wu, Shahid Ahmed, Andrew Freywald, Rajni Chibbar, Yue Wu, Mike Moser, Gary Groot, Wenjun Zhang, Bing Zhang, Jim Xiang
Topics & Concepts
TLR3Tumor microenvironmentCancer researchCD8BlockadeImmunotherapyImmune systemT cellCpG OligodeoxynucleotideCancer immunotherapyImmunologyCell biologyChemistryInnate immune systemBiologyToll-like receptorReceptorGene expressionGeneDNA methylationBiochemistryMicrobial Inactivation MethodsCAR-T cell therapy researchToxin Mechanisms and Immunotoxins