Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H<sub>3</sub> and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
Katarzyna Szczepańska, Sabina Podlewska, Maria Dichiara, Davide Gentile, Vincenzo Patamia, Niklas Rosier, Denise Mönnich, M. Carmen Ruiz‐Cantero, Tadeusz Karcz, Dorota Łażewska, Agata Siwek, Steffen Pockes, Enrique J. Cobos, Agostino Marrazzo, Holger Stark, Antonio Rescifina, Andrzej J. Bojarski, Emanuele Amata, Katarzyna Kieć‐Kononowicz
Abstract
R ligands in various pain models, our research might be a breakthrough in the search for novel, dual-acting compounds that can improve existing pain therapies. Determining whether such ligands are more effective than single-selective drugs will be the subject of our future studies.
Topics & Concepts
PiperazinePiperidineSigma receptorPharmacologySigma-1 receptorNociceptionHistamine receptorChemistryHistamineReceptorMedicineStereochemistryBiochemistryAntagonistAgonistPharmacological Receptor Mechanisms and EffectsPhenothiazines and Benzothiazines Synthesis and ActivitiesCholinesterase and Neurodegenerative Diseases