Protein transport along the presequence pathway
Abhijith Makki, Peter Rehling
Abstract
Abstract Most mitochondrial proteins are nuclear-encoded and imported by the protein import machinery based on specific targeting signals. The proteins that carry an amino-terminal targeting signal (presequence) are imported via the presequence import pathway that involves the translocases of the outer and inner membranes – TOM and TIM23 complexes. In this article, we discuss how mitochondrial matrix and inner membrane precursor proteins are imported along the presequence pathway in Saccharomyces cerevisiae with a focus on the dynamics of the TIM23 complex, and further update with some of the key findings that advanced the field in the last few years.
Topics & Concepts
Translocase of the inner membraneProtein targetingMitochondrial membrane transport proteinSaccharomyces cerevisiaeInner membraneCell biologyMitochondrionTransport proteinInner mitochondrial membraneMitochondrial carrierTranslocase of the outer membraneMembrane transportBiochemistryChemistryBacterial outer membraneMembrane proteinBiologyYeastMembraneGeneEscherichia coliMitochondrial Function and PathologyRNA and protein synthesis mechanismsRNA modifications and cancer