PET imaging of macrophages in cardiovascular diseases.
Xiang Li, Zachary T. Rosenkrans, Jing Wang, Weibo Cai
Abstract
F-FDG can be taken up by active macrophages, the PET imaging tracer is non-specific and susceptible to blood glucose levels. Thus, developing more specific PET tracers will help us understand the role of macrophages in CVDs. Moreover, macrophage-targeted PET imaging will further improve the diagnosis, treatment monitoring, and outcome prediction for patients with CVDs. In this review, we summarize various targets-based tracers for the PET imaging of macrophages in CVDs and highlight research gaps to advise future directions.
Topics & Concepts
MedicinePositron emission tomographyPet imagingMacrophageMolecular imagingCardiac imagingIntensive care medicinePathologyRadiologyIn vivoBiotechnologyBiochemistryChemistryIn vitroBiologyMedical Imaging Techniques and ApplicationsCardiac Imaging and DiagnosticsS100 Proteins and Annexins