Metal-free synthesis of 3,3′-bisindolylmethanes in water using Ph<sub>3</sub>C<sup>+</sup>[B(C<sub>6</sub>F<sub>5</sub>)<sub>4</sub>]<sup>−</sup> as the pre-catalyst
Zhenguo Zhang, Liang Ji, Xiaoxiao Liu, Zhihong Li, Yongheng Lv, Zhenhua Jia, Teck‐Peng Loh
Abstract
We described an efficient catalytic species generated from Ph 3 C + [B(C 6 F 5 ) 4 ] − by the water mediated Friedel–Crafts type reaction of indoles with carbonyl compounds to access 3,3′-bisindolylmethanes (BIMs).
Topics & Concepts
ChemistryCatalysisMetalStereochemistryMedicinal chemistryOrganic chemistrySynthesis of Indole DerivativesChemical Synthesis and ReactionsFluorine in Organic Chemistry